Many lines of research hold similar promise for
controlling biology to build useful things.
Predictions do not always come true. What's new about
this latest effort is that the bacteria are made to
communicate, so that millions or even billions of them
gather in a predictable manner.
And there are pictures to prove it.
The researchers programmed E. coli bacteria
to emit red or green fluorescent light in response to
a signal emitted from another set of E. coli.
The living cells were commanded to make a bull's-eye
pattern, for example, around central cells based
on communication between the bacteria.
Other patterns produced with this new "synthetic
biology" technique include a pretty good semblance
of a heart and a rudimentary flower
pattern.
The work was led by Ron Weiss, an assistant
professor of electrical engineering and molecular
biology at Princeton University.
Weiss and his colleagues engineer a special segment
of DNA, the blueprints for any cell's operations. The
segment is called a plasmid.
"You have a segment of DNA that dictates when
proteins should be made and under what conditions,"
Weiss told LiveScience. The plasmid is inserted
into a cell, and "the cell then executes the set of
instructions."
While most real-world applications of the technique
are likely many years away, Weiss said it might be
used in three to five years to make devices that could
detect bioterrorism chemicals.
The bacteria "have an exquisite capability to sense
molecules in the environment," he said. "The
bull's-eye could tell you: This is where the anthrax
is."
The study is detailed in April 28 issue of the
journal Nature.
In a paper March 8 in the Proceedings of the
National Academy of Sciences, another team led by
Weiss showed they could insert DNA into cells to make
them behave like digital circuits. The cells could be
made to perform basic mathematical logic. The latest
work expands this concept to vast numbers of bacteria
responding in concert.
"Here we're showing an integrated package where the
cells have an ability to send messages and other cells
have the ability to act on these messages," Weiss
said.